Stability of monoHER in an aqueous formulation for i.v. administration |
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| Authors: | Abou El Hassan M A Touw D J Wilhelm A J Bast A van der Vijgh W J |
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| Affiliation: | Department of Medical Oncology, Free University Hospital, P. O. Box 7057, 1007 MB, Amsterdam, The Netherlands. m.abulhassan@azvu.nl |
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| Abstract: | MonoHER is a semisynthetic flavonoid used successfully in modulating the cardiotoxic effect of doxorubicin but not its antitumor activity. The oral bioavailability of monoHER is <1%. Therefore, it should be prepared as an i.v. formulation for use in clinical trials. The solubility of monoHER in water is highly pH dependent. At pH
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