菊糖对大鼠肠源性高草酸尿症的疗效

目的 观察菊糖对大鼠肠源性高草酸尿症的疗效。方法 实验1:健康雄性 SD 大鼠24只,分别在第1、2、3天给予无草酸饲料、草酸含量为74.82 mg/100 g饲料、草酸含量为74.82 mg/100 g饲料,并在第3天另外给予每只大鼠2 g菊糖,检测大鼠每天的24 h尿量、尿草酸浓度、尿肌酐浓度,并计算24 h尿草酸总排泄量。实验2:健康雄性SD大鼠24只,随机分成对照组和实验组,每组12只,均给予草酸含量为74.82 mg/100 g的高草酸饲料,实验组大鼠另给予2 g菊糖,检测并计算出两组大鼠的24 h尿草酸总排泄量。结果 实验1:时间因素对24 h尿草酸总排泄量有显著影响(F=11.481,P=0.035),第2天大鼠的24 h尿草酸总排泄量明显高于第1天(P=0.026)和第3天(P=0.037),第3天也明显高于第1天(P=0.004)。实验2:实验组大鼠24 h尿草酸总排泄量明显低于对照组(P=0.011)。结论 菊糖对大鼠高草酸尿症可能有潜在治疗价值。

Therapeutic Effect of Inulin on Enteric Hyperoxaluria in Rats

Objective To observe the therapeutic effect of inulin on enteric hyperoxaluria in rats. Methods In experimental A,24 healthy male Sprague-Dawley rats received an oxalate-free diet on day 1,a high-oxalate diet(oxalate,74.82 mg/100 g feed stuffs)on days 2 and 3,and plus 2 g inulin to each rat on day 3. The 24-hour urinary volume,concentrations of urinary oxalate and urine creatinine were measured,and 24-hour urinary oxalate excretion was calculated. In experimental B,24 healthy male Sprague-Dawley rats were equally randomized into control group and inulin group,Each rat received a high oxalate diet(oxalate,74.82 mg/100 g feedstuffs),and plus 2 g inulin in inulin group. The 24-hour urinary oxalate excretion was calculated in both two groups. Results In experimental A,the 24-hour urinary oxalate excretion varied with time(F=11.481,P=0.035). The 24-hour urinary oxalate excretion significantly increased on day 2 compared with that on day 1(P=0.026)and day 3(P=0.037);it significantly increased on day 3 compared with day 1(P=0.004). In experimental B,the 24-hour urinary oxalate excretion significantly decreased in inulin group compared with the control(P=0.011). Conclusion Inulin may have potential therapeutic effect on enteric hyperoxaluria in rats.