| 微小RNA与胃癌 |
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| 引用本文： | 田树波,于健春,康维明,马志强,叶欣,曹战江. 微小RNA与胃癌[J]. 中国医学科学院学报, 2014, 36(2): 214-217. DOI: 10.3881/j.issn.1000-503X.2014.02.020 |
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| 作者姓名： | 田树波 于健春 康维明 马志强 叶欣 曹战江 |
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| 作者单位： | 中国医学科学院 北京协和医学院 北京协和医院基本外科,北京 100730 |
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| 基金项目： | :北京市自然科学基金(7132209) |
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| 摘 要： | 胃癌的发生是基因和环境共同作用的结果。微小RNA(miRNA)分子可以调控细胞的增殖、分化和凋亡等过程,并对胃癌的发生、发展发挥重要的调节作用。近年来,miRNA与胃癌的相关性研究不断深入,从miRNA表达谱研究、miRNA与表观遗传相互调控及幽门螺杆菌感染相关miRNA等方面揭示了miRNA在胃癌发生发展中的作用。miRNA在血液中有高稳定性,循环miRNA无创诊断胃癌有着广阔的临床应用前景。
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| 关 键 词： | 微小RNA 胃癌 表观遗传 |
| 收稿时间： | 2013-12-13 |
MicroRNA and Gastric Cancer |
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| TIAN Shu-bo,YU Jian-chun,KANG Wei-ming,MA Zhi-qiang,YE Xin,CAO Zhan-jiang. MicroRNA and Gastric Cancer[J]. Acta Academiae Medicinae Sinicae, 2014, 36(2): 214-217. DOI: 10.3881/j.issn.1000-503X.2014.02.020 |
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| Authors: | TIAN Shu-bo YU Jian-chun KANG Wei-ming MA Zhi-qiang YE Xin CAO Zhan-jiang |
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| Affiliation: | Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China |
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| Abstract: | Gastric cancer is caused by the interaction of genetic and environmental factors. MicroRNA(miRNA)is involved in many cellular processes including proliferation,differentiation,and apoptosis and plays an important role in pathogenesis of gastric cancer,as demonstrated in many recent studies from perspectives including miRNA profiling,reciprocal modulation between epigenetic and miRNA,and Helicobacter pylori infection. MiRNA is highly stabe in blood,and therefore non-invasive diagnosis of gastric cancer using circulating miRNA may be promising. |
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| Keywords: | Key words:microRNA gastric cancer epigenetic |
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