左侧壳核软化灶致右侧肢体疼痛:人脑边缘区静息态功能磁共振成像

目的 采用静息态脑功能成像研究边缘区在疼痛中的作用机制。方法 对1例左侧壳核软化灶导致右侧躯体偏身疼痛患者及8名健康志愿者进行静息态脑功能成像研究,手工勾画边缘区蒙片,进行全脑基于感兴趣区的功能连接计算。结果 左侧边缘区功能连接较健康对照显著下降,主要位于双侧尾状核头、壳核及左侧苍白球。结论 边缘区可能参与人类疼痛调节,机制尚有待于进一步研究。

Right Extremities Pain Caused by A Malacia Lesion in the Left Putamen:A Resting Functional Magnetic Resonance Imaging of the Marginal Division of the Human Brain

Objective To explore the role of marginal division of the human brain in the pain modulation.Methods Resting functional magnetic resonance imaging was applied in a patient with right extremities pain caused by a malacia lesion in the left putamen and in 8 healthy volunteers.Marginal division was defined using manual drawing on structure images,and was applied to the computation of fuctional connectivity maps.Results The functional connectivities in the left marginal division showed an evident decrease in the patient when compared with healthy controls.These connectivities were mainly located in the bilateral head of caudate nucleus,putamen,and left globus pallidus.Conclusion The marginal division may be involved in the pain modulation.