益气固本汤联合穴位贴敷对儿童支气管哮喘疗效和免疫功能的影响

目的:观察益气固本汤联合穴位贴敷对支气管哮喘儿童吸入激素治疗疗效和免疫功能的影响。方法:随机将2012年10月—2014年8月收治我院的86例哮喘患儿分为两组,对照组给予吸入激素治疗,观察组在对照组的基础上,观察组给予益气固本汤联合穴位贴敷治疗,观察两组的治疗临床疗效、哮喘发作次数、感冒次数、治疗前后细胞免疫及体液免疫功能指标。结果:1治疗6个月后,观察组的总有效率为86.05%,对照组的总有效率为72.09%,组间差异无统计学意义。治疗12个月后,观察组的总有效率为95.35%,对照组的总有效率为81.40%,组间差异有统计学意义(P0.05)。2治疗期间,观察组哮喘发作次数为(2.8±0.3)次,对照组哮喘发作次数为(3.1±0.4)次,组间差异具有统计学意义(P0.05);观察组感冒次数为(2.1±0.3)次,对照组感冒次数为(3.4±0.2)次,组间差异具有统计学意义(P0.05)。3观察组治疗前的CD3+,CD4+,CD8+较对照组差异均不显著;治疗后,两组的CD3+,CD4+较治疗前高,CD8+较治疗前低,差异显著(P0.05)。且观察组治疗后的CD3+,CD4+较对照组高,CD8+较对照组低,组间差异显著(P0.05)。4观察组治疗前的Ig A,Ig E,Ig G,Ig M,胰岛素样生长因子-I(IGF-I)较对照组差异均不显著;治疗后,两组的Ig A,Ig G,Ig M,IGF-I较治疗前高,Ig E较治疗前低,差异显著(P0.05)。且观察组治疗后的Ig A,Ig G,Ig M,IGF-I较对照组高,Ig E较对照组低,组间差异显著(P0.05)。结论:益气固本汤联合穴位贴敷治疗支气管哮喘患儿的临床疗效显著,能缓解哮喘患儿的临床症状,降低支气管哮喘患儿的哮喘复发率,增强细胞免疫和体液免疫功能。

Influence of Effect and Immune Function in Children with Bronchial Asthma After Therapy of Inhaled Corticosteroid by Therapy for Yiqi Guben Tang Combined with Acupoint Sticking

Objective: The purpose of this study was to observe the influence of effect and immune function in children with bronchial asthma after therapy of inhaled corticosteroid by treatment of Yiqi Guben Tang combined with acupoint sticking. Method: In this study, 86 children with bronchial asthma from October 2012 to August 2014 were randomly divided into two groups. The control group was given therapy of inhaled corticosteroid, on the basis of control group, the observation group was given therapy of Yiqi Guben Tang combined with acupoint sticking, then clinical curative effect, the number of asthma attacks and colds, indexes of cellular immunity and humoral immunity function before and after treatment were observed. Result: After treatment of 6 months, total effective rate in observation group was 86.05%, while total effective rate in control group was 72.09%, there was no statistically significant difference between the two groups. After treatment of 12 months, total effective rate in observation group was 95.35%, total effective rate in control group was 81.40%, with no statistically significant difference between the two groups. During the treatment, asthma attack frequency in observation group was (2.8±0.3) times, that in control group was (3.1±0.4) times, there was statistically significant difference between the two groups (P <0.05);cold frequency in observation group was (2.1±0.3) times, that in control group was (3.4±0.2) times, there was statistically significant difference between the two groups (P< 0.05). Difference of CD3⁺, CD4⁺, CD8⁺ before treatment between the two groups had no significant difference;after treatment, CD3⁺ and CD4 ⁺ of both two groups were higher than before treatment, while CD8⁺ was lower, with significant difference (P <0.05). CD3⁺ and CD4⁺ after treatment in observation group were higher than those in control group, while CD8⁺ was lower, with significant difference between both groups (P <0.05). IgA, IgM, IgE, IgG and insulin-like growth factor(IGF-I) before treatment between groups had no significant difference;after treatment, IgA, IgG, IgM and IGF-I of two groups were higher than before treatment, while IgE was lower, with significant difference (P <0.05). IgA, IgG, IgM and IGF-I after treatment in observation group were higher than those in control group, while IgE was lower, with significant difference between groups (P <0.05). Conclusion: The clinical efficacy of therapy of Yiqi Guben Tang combined with acupoint sticking in the treatment of children with bronchial asthma was significant, it can alleviate clinical symptoms of asthmatic children, reduce the recurrence of asthma in children with bronchial asthma, strengthen the function of cellular immunity and humoral immunity.