慢性阻塞性肺疾病的发病机制及中医药治疗进展

慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)属呼吸系统的常见病,其发病率、死亡率均高。本文对有关COPD发病机制及中医药研究文献进行分析,结合自身科研结果,总结COPD发病机制主要与肺部炎症、气道黏液过度分泌、氧化/抗氧化失衡、蛋白酶/抗蛋白酶失衡、细胞凋亡/组织重构等有关;基于发病机制,探寻防治COPD新的药物作用靶点,中医药因多途径、多靶点作用,治疗COPD凸显优势,与此相关的COPD基础和临床研究在不断深入。

Research Progress of Chronic Obstructive Pulmonary Disease in Mechanism and Treatment of Traditional Chinese Medicine

The chronic obstructive pulmonary disease (COPD) is a common disease of respiratory system, its morbidity and mortality are higher. The lung function decreases gradually, the labor force and the quality of life of patients was affected seriously. It is gradually understood with knowledge of COPD in recent years,the relevant pathogenesis of COPD and research literature of traditional Chinese medicine on COPD are analyzed in this paper.Based o the results of our scientific research,pathogenesis of COPD relevant with inflammation, airway mucus secretion of excessive, oxidation/antioxidant imbalance, reconstruction were viewed. From the point of pathogenesis,the therapeutic methods are important in finding action targets for COPD, and it was of traditional Chinese medicine has certain advantages in treatment of COPD.