| CD4＋CD25＋Treg细胞与支气管哮喘 |
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| 引用本文： | 鞠云飞,孙立锋,胡华.CD4＋CD25＋Treg细胞与支气管哮喘[J].中华哮喘杂志（电子版）,2011,5(6):439-441. |
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| 作者姓名： | 鞠云飞 孙立锋 胡华 |
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| 作者单位： | 1. 山东省胸科医院呼吸科,济南,250013
2. 山东大学附属省立医院儿科,济南,250021 |
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| 摘 要： | CD4＋CD25＋Treg细胞的主要作用表现为免疫无能性和免疫抑制性，是外周免疫耐受形成机制的主要组成部分。其主要作用机制为分泌抑制性细胞因子（IL-10和TGF-β）、表达细胞表面分子（CTLA-4、GITR等）及Foxp3等。支气管哮喘患者外周血CD4＋CD25＋Treg功能及数量存在异常，这可能是支气管哮喘发病机制之一。糖皮质激素可以通过影响CD4＋CD25＋Treg的状态起到抑制支气管哮喘气道炎症的作用。
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| 关 键 词： | 调节性T细胞 哮喘 糖皮质激素 |
CD4+CD25+Treg cells and bronchial asthma |
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| JU Yun-fei,SUN Li-feng,HU Hua.CD4+CD25+Treg cells and bronchial asthma[J].Chinese Journal of Asthma(Electronic Version),2011,5(6):439-441. |
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| Authors: | JU Yun-fei SUN Li-feng HU Hua |
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| Institution: | JU Yun-fei,SUN Li-feng,HU Hua.Department of Respiratory Medicine,Chest Hospital of Shandong Province,Jinan 250013,China |
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| Abstract: | The main function of CD4＋ CD25＋ Treg cells are immunological anergy and inhibition, which is essential to the maintenance of immunological tolerance in the host. CD4＋ CD25＋ Treg cells produce inhibitory cytokines （TGF-13 and IL-10）, express membrane molecules （CTLA-4,GITR,etc） and Foxp3. There are abnormal in function and quantity of CD4＋ CD25＋ Treg cells of peripheral blood from asthmatic patients, which maybe one of the pathogenesis of asthma. Glucocorticoids can inhibit the airway inflamation of asthma by impacting CD4＋ CD25＋ Treg cells. |
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| Keywords: | Regulatory T cells Asthma Glucocorticoids |
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