妊娠期高血压疾病孕妇血及脐血中抑制素及表皮生长因子水平的变化

目的探讨妊娠期高血压疾病孕妇血及其分娩的新生儿脐血血浆中抑制素(INH)和表皮生长因子(EGF)的水平变化及其对妊娠期高血压疾病发病及胎儿生长发育的影响。方法采用酶联免疫吸附试验(ELISA),检测65例妊娠期高血压疾病患者(观察组)及21例正常妊娠妇女(对照组)及其分娩的新生儿脐血血浆中INH、EGF水平。结果观察组孕妇血浆INH水平为(499±52)ng／L,对照组为(421±36)ng／L,两组比较,差异有统计学意义(P<0．01)。观察组新生儿脐血INH水平为(274±53)ng／L,对照组为(252±28)ng／L,两组比较,差异无统计学意义(P>0．05)。观察组EGF水平为(408±60)ng／L,对照组为(463±87)ng／L,两组比较,差异有统计学意义(P< 0．05)。观察组新生儿脐血中EGF水平为(232±99)ng／L,对照组为(380±97)ng／L,两组比较,差异也有统计学意义(P<0．01)。脐血中EGF水平与新生儿体重呈正相关关系(r=0．326,P<0．05),与胎盘重量呈正相关关系(r=0．451,P<0．05)。结论孕妇血浆中INH、EGF水平与妊娠期高血压疾病的发病有关,脐血中EGF水平对胎儿及胎盘的生长发育有影响。

Changes of maternal plasma and umbilical cord plasma inhibin and epidermal growth factor in patients with hypertensive disorder complicating pregnancy

OBJECTIVE: To study the levels of inhibin (INH) and epidermal growth factor (EGF) in maternal plasma and umbilical cord plasma of patients with hypertensive disorder complicating pregnancy, and to explore their influence on the disease and fetal growth. METHODS: Enzyme linked immunosorbent assay (ELISA) was used to detect maternal and umbilical cord plasma INH and EGF levels in 65 patients with hypertensive disorder complicating pregnancy (test groups) and 21 normal pregnant women (control group). RESULTS: Plasma level of INH in test groups (499 +/- 52) ng/L was significantly higher than that (421 +/- 36) ng/L in control group (P < 0.01); however, the umbilical cord plasma level of INH had no significant difference (P > 0.05). Plasma level of EGF in test groups (408 +/- 60) ng/L was significantly lower than that (463 +/- 87) ng/L in control group (P < 0.05), also there was significant difference in umbilical cord plasma level of two groups (232 +/- 99) ng/L vs (380 +/- 97) ng/L (P < 0.01). The level of EGF in umbilical cord blood was positively correlated with newborn's body weight and placental weight. CONCLUSIONS: Plasma levels of INH and EGF in pregnancy women are related with hypertensive disorder complicating pregnancy. EGF level of umbilical cord blood affects the growth of fetus and placenta.