移居高原习服者血清胆红素浓度变化及意义

 目的 探讨移居高原习服者血清胆红素演变规律及其临床意义.方法 将140名官兵按移居时间分为组1(0.5～1年,n＝50)、组2(2～4年,n＝30)、组3(5～10年,n＝30)和组4(＞10年,n＝30).检测血清总胆红素(T-Bil)、直接胆红素(D-Bil)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-c)和门冬氨酸氨基转移酶(AST).结果 与组1和组2比较,组3和组4 T-Bil显著下降(P＜0.01);与组1比较,组3和组4 TC增高(P＜0.05);与组1比较,组4 AST增高(P＜0.05);D-Bil、TG和HDL-c在各组间差异均无统计学意义(P＞0.05).结论 T-Bil减低及TC和AST增高,可能与移居高原习服者罹患冠心病风险增加有关,T-Bil改变与D-Bil无关.

Change in serum bilirubin concentrations and its clinical significance in servicemen acclimatized to living in plateau

Objective To explore the variational regularities and clinical significance of serum bilirubin in servicemen acclimatized to living in plateau.Methods 140 acclimatized soldiers were divided into 4 groups: 1st group (0.5-1 year,n=50), 2nd group(2-4 years,n=30),3rd group(5-10 years,n=30), and 4th group(>10 years,n=30).The levels of total bilirubin(T-Bil), direct bilirubin(D-Bil), triglycerides(TG), total cholesterol(TC), and aspartate aminotransferase(AST) in their serum were determined.Results The levels of T-Bil in the 3rd group and the 4th group were significantly lower than those in the 1st group and 2nd group(P<0.01). The levels of TC in the 3rd group and the 4th group were significantly higher than that in the 1st group(P<0.05). The level of AST in the 4th group was significantly higher than that in the 1st group(P<0.05). No significant differences were observed in the levels of D-Bil, TG, and HDL-c between all observed groups(P>0.05).Conclusion The decrease in levels of T-Bil and the increase in levels of TC and AST in serum might be associated with the increased risk of the prevalence of coronary artery disease among soldiers in plateau. The association of variations of the levels of T-Bil with the levels of the D-Bil in serum was not found.