| 镁对海马神经元钙激活钾通道的作用 |
| |
| 引用本文： | 唐兴江,李小刚,范生尧,贺军,李妙龄,杨艳,曾晓荣. 镁对海马神经元钙激活钾通道的作用[J]. 卒中与神经疾病, 2001, 8(1): 23-25 |
| |
| 作者姓名： | 唐兴江 李小刚 范生尧 贺军 李妙龄 杨艳 曾晓荣 |
| |
| 作者单位： | 1. 四川泸州，泸州医学院附属医院神经内科 646000
2. 泸州医学院心肌电生理研究室 |
| |
| 摘 要： | 目的研究Mg
|
| 关 键 词： | 钙激活钾通道 海马神经元 膜片钳制技术 镁离子 |
| 文章编号： | 1007-0478(2001)01-0023-03 |
The effects of magnisium ions on Ca~(2 )-activated potassium channels in rat hippocampal neurons |
| |
| Tang Xingjiang. The effects of magnisium ions on Ca~(2 )-activated potassium channels in rat hippocampal neurons[J]. Stroke and Nervous Diseases, 2001, 8(1): 23-25 |
| |
| Authors: | Tang Xingjiang |
| |
| Abstract: | Objective Effects of Mg 2 on Ca 2 -activated potassium channels in cultured newborn rat hippocampal neurons were studied to reveal the electrophysiological mechanism about the effects of Mg 2 on the neurons of cerebral ischemia.Methods Inside-out method of patch clamp technique was used to record the activity of single channel, configurational application of p-CLAMP software for data sampling storing and analysing. Results After magnesium ions was applied to the cytoplasmic face of the channels, activation of Mg 2 on Ca 2 -activated potassium channels was found. It increased dose-dependently their open probability and shortened the closed time of the channels. Conclusion Mg 2 may protect the neurons by activating the Ca 2 -activated potassium channels. |
| |
| Keywords: | Ca 2 activated potassium channels Hippocampal neurons Patch clamp technique Mg 2 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
