| 异丙酚对大鼠肝缺血再灌注时肾脏的保护作用 |
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| 引用本文： | 陈晖,韩曙君,雷志礼.异丙酚对大鼠肝缺血再灌注时肾脏的保护作用[J].武警医学,2005,16(5):349-351. |
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| 作者姓名： | 陈晖 韩曙君 雷志礼 |
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| 作者单位： | 武警总医院麻醉科,北京,100039 |
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| 摘 要： | 目的 探讨异丙酚在肝缺血/再灌注(I/R)后对肾脏的保护作用。方法 SD大鼠72只随机分为3组,( 1)正常对照组( 2 )I/R组( 3)异丙酚保护组。于肝I/R后2h ,4h分别检测血清BUN、Cr及肾组织病理学变化。结果 与正常对照组比较,I/R组血中BUN、Cr水平显著增加,4h组高于2h组(P <0 .0 5 ) ,而异丙酚保护组BUN、Cr水平则低于I/R组。结论 异丙酚能减少肝I/R对肾脏的损伤作用
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| 关 键 词： | 异丙酚 再灌注损伤 肾 |
| 修稿时间： | 2005年3月21日 |
Protective effects of propofol on renal injury during liver ischemia/reperfusion |
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| CHEN Hui,HAN Shujun,LEI Zhili.Protective effects of propofol on renal injury during liver ischemia/reperfusion[J].Medical Journal of the Chinese People's Armed Police Forces,2005,16(5):349-351. |
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| Authors: | CHEN Hui HAN Shujun LEI Zhili |
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| Institution: | CHEN Hui,HAN Shujun,and LEI Zhili.Department of Anesthesiology,General Hospital of Chinese People's Armed Police Forces,Beijing 100039,China |
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| Abstract: | Objective To investigate the long-term renal injury after liver ischemia/reperfusion(I/R) and the renal protection afforded by propofol.Methods 72 male SD rats were randomly divided into three groups:normol control group,I/R group and propofol group.The animals were killed after 60 minutes ischemia of liver followed by reperfusion for 4 hours.2 and 4 hours,after I/R BUN and Cr were detected,and renal histopathologic lesions were examined.Results In I/R group,BUN and Cr serum levels increased significantly after I/R,compared with the baseline values before liver I/R,while propofol decreased the serum levels of BUN and Cr significantly.Conclusion Propofol alleviates the renal injury during liver I/R. |
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| Keywords: | Propofol Reperfusion injury Kidneys |
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