| 参附注射液对大鼠心肌缺血再灌注损伤保护作用的实验研究 |
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| 引用本文： | 苏泓洁,向小勇,赵兴吉,都定元. 参附注射液对大鼠心肌缺血再灌注损伤保护作用的实验研究[J]. 重庆医科大学学报, 2010, 35(1) |
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| 作者姓名： | 苏泓洁 向小勇 赵兴吉 都定元 |
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| 作者单位： | 重庆医科大学附属第一医院胸心外科,重庆,400016;重庆市急救医疗中心胸心外科,重庆,400014 |
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| 摘 要： | 目的:探讨参附注射液(Shen fu injection,SFI)对心肌缺血再灌注损伤(Myocardial ischemia-reperfusion iniury,MIRI)的功效.方法:通过复制大鼠心肌缺血再灌注损伤模型,观察SFI不同剂量对心肌缺血再灌注损伤的保护作用.结果:SFI高剂量组对大鼠心肌缺血再灌注损伤模型组在给药后30、60、120 min能明显降低大鼠ECG的ST段和T波的偏移,有显著性差异(P<0.05);在给药后120min能明显降低大鼠血清CK、CK-MB、LDH和MMP-9的活性,有显著性差异(P<0.05);还能显著降低大鼠心室脏器系数,使其心肌梗塞面积明显缩小,梗塞区重量减轻,明显改善心肌缺血状况;对冠脉结扎再灌注损伤大鼠全血粘度(低切)和血浆粘度的升高有一定的降低作用.结论:SFI对大鼠心肌缺血再灌注损伤有明显的保护作用,为其临床应用提供了进一步的实验室依据.
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| 关 键 词： | 参附注射液 心肌缺血再灌注损伤 基质金属蛋白酶-9 |
An experimental study on the protective effects of shenfu injection for myocardial ischemia-reperfusion injury in rats |
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| SU Hong-jie,et al. An experimental study on the protective effects of shenfu injection for myocardial ischemia-reperfusion injury in rats[J]. Journal of Chongqing Medical University, 2010, 35(1) |
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| Authors: | SU Hong-jie et al |
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| Affiliation: | SU Hong-jie,et al(Department of Cardiothoracic Surgery,the First Affiliated Hospital,Chongqing Medical University) |
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| Abstract: | Objective:To investigate the function ofshenfu injection in myocardial ischemia-reperfusion injury(MIRI).Methods:To observe the effects of Shenfu injection(SFI)in different dosages.An experimental rat's model of myocardial ischemia-reperfusion inury(MIRI)was created.Results:The high-dosed-Shenfu-injection(SFI)group(20 ml/kg)compared with the MIRI model group showed significant depressant effect on the ECG ST segment and T wave after 30,60,120 minutes,respectively,of the injection.Such differences were of gr... |
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| Keywords: | Shenfu injection Myocardial ischemia-reperfusion injury Matrix metalloproteinase-9 |
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