| 海兰地嗪对血小板聚集的影响及机理探讨 |
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| 引用本文： | 马丽娟 尹钟洙. 海兰地嗪对血小板聚集的影响及机理探讨[J]. 中国药理学与毒理学杂志, 1991, 5(1): 41-43 |
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| 作者姓名： | 马丽娟 尹钟洙 |
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| 作者单位： | 中日友好医院临床医学研究所药物药理室，中日友好医院临床医学研究所药物药理室，中日友好医院临床医学研究所药物药理室 北京 100029，北京 100029，北京 100029 |
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| 摘 要： | 海兰地嗪(Her)体外对胶原,ADP,A23187和AA诱导的大鼠血小板聚集有明显抑制作用,其IC_(50)分别为14.5,41.6,44.1和48.3μg/ml。Her对AA诱导的大鼠血小板MDA生成不能抑制,但能升高兔血小板cAMP水平和抑制凝血酶诱导的人血小板胞浆内游离钙离子浓度升高。Her的抗血小板聚集作用机理可能与升高血小板内cAMP水平和抑制细胞内游离钙离子浓度升高有关。
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| 关 键 词： | 海兰地嗪 血小板聚集 丙二醛 3,5′-环磷酸腺苷 细胞内游离钙离子 |
Effect of hernandezine on platelet aggregation and its mechanism of action |
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| MA Li-Juan,YIN Zhong-Zhu,LIU Gan-ZhongInst Clinical Medical Sciences,China-Japan Friendship Hospital,Beijing. Effect of hernandezine on platelet aggregation and its mechanism of action[J]. Chinese Journal of Pharmacology and Toxicology, 1991, 5(1): 41-43 |
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| Authors: | MA Li-Juan YIN Zhong-Zhu LIU Gan-ZhongInst Clinical Medical Sciences China-Japan Friendship Hospital Beijing |
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| Affiliation: | MA Li-Juan,YIN Zhong-Zhu,LIU Gan-ZhongInst Clinical Medical Sciences,China-Japan Friendship Hospital,Beijing 100029 |
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| Abstract: | Hernandezine, an isoquinoline alkaloid, is one of the active ingredients isolated from Thalictrum glandulosissimum. It was found to inhibit markedly rat platelet aggregation induced by collagen, ADP, calicimycin (A-23187) and arachidonic acid (AA) in vitro. The IC50 were 14.5, 41.6, 44.1 and 48.3μg/ml, respectively. Hernandezine (25, 50 and 100 μg / ml) could not inhibit the formation of MDA in-duced by AA. Hernandezine could increase the concentration of cAMP in rabbit platelet and inhibit the increase of the cytosolic free Ca2+ concentration in human platelet induced by thrombin. |
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| Keywords: | hernandezine platelet aggregation malondialdehyde 3 5'-cyclic adenylic acid cytosolic free Ca2+ |
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