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| 包衣工艺参数对马来酸替加色罗pH依赖型缓释片释放度的影响 | |
| 引用本文： | 王桂玲,张双庆,张毅. 包衣工艺参数对马来酸替加色罗pH依赖型缓释片释放度的影响[J]. 中国实验方剂学杂志, 2010, 16(3): 4-7 |
| 作者姓名： | 王桂玲 张双庆 张毅 |
| 作者单位： | 1. 北京大学药学院药剂学系,北京,100191 2. 军事医学科学院毒物药物研究所,北京,100850 3. 中国中医科学院中药研究所,北京,100700 |
| 摘 要： | 目的:研究各种包衣工艺参数对马来酸替加色罗pH依赖型缓释片释放度的影响。方法:考察包衣温度,包衣锅转速,雾化压力,喷雾速度,喷雾距离和包衣液预热温度对缓释片药物释放度的影响,并用相似因子法对释放度进行评价。结果:在所考察的各个包衣工艺参数水平上,包衣温度对药物释放度有显著影响,其余各因素无显著影响。结论:确定最终包衣工艺参数为:包衣温度为30℃,包衣锅转速为25 rpm,雾化压力0.6 MPa,喷雾速度为5 mL.min-1,喷雾距离17 cm。包衣液预热温度为30℃。 |
| 关 键 词： | 马来酸替加色罗 pH依赖型缓释片 包衣工艺参数 |
| 收稿时间： | 2009-10-13 |
Effects of Coating Parameters on Release rate of a pH-dependent Sustained Release Tablet of Tegaserod Maleate |
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| WANG Gui-ling,ZHANG Shuang-qing and ZHANG Yi. Effects of Coating Parameters on Release rate of a pH-dependent Sustained Release Tablet of Tegaserod Maleate[J]. China Journal of Experimental Traditional Medical Formulae, 2010, 16(3): 4-7 | |
| Authors: | WANG Gui-ling ZHANG Shuang-qing ZHANG Yi |
| Affiliation: | Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China;Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China |
| Abstract: | Objective:To investigate the effects of various coating parameters on release of a pH-dependent sustained release tablet of tegaserod maleate.Methods: Coating parameters,such as coating temperature,rotation speed of coating pan,spray pressure,spray rate,spray distance and coating solution temperature,were evaluated and the release was in vestigated by similarity factor.Results: Coating temperature significantly affected drug release while other parameters hed on obvious influence on drug release.Conclusion:... |
| Keywords: | tegaserod maleate pH-dependent sustained release tablet coating parameters |
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