89例重型病毒性肝炎死亡的病原学分析

该文对８９例死亡重型肝炎（重肝）患者（急重型２例，亚重型２０例，慢重型６７例）进行了病原学及单一、混合感染血清学分析。结果提示重肝以ＨＢＶ感染为主，目前大部分为慢重型，且以乙、丙型多见。前二者混合感染引起的重肝预后严重；在ＨＢＶ感染的基础上重叠ＨＥＶ是本病重型化的主要原因之一，而孕妇尤甚。同时不少重肝缺乏ＨＢＶ感染的血清学标志，除与病毒本身变异，尚与宿主的免疫应答及其它肝炎病毒的感染有关。

Pathogen Analysis of 89 Dead Cases of Fulminant Viral Hepatitis

This paper reported 89 cases of fulminant hepatitis (2 cases of acute fulminant hepatitis, 20 subacute, and 67 chronic respectively). The results of pathogenicity as well as serologic detection infected by single and mixed viruses were analysed. The data showed that the main pathogen of fulminant hepatitis was HBV. Most cases of hepatitis B were chronic ones. Hepatitis B and C were more common. The fulminant hepatitis caused by HBV accompaning with HCV presented prognosis mala. HBV superinfected with HEV was one of the main causes for hepatitis exacerbation, and this exacerbation was worse in the pregnancy. At the same time, many patients of fulminant hepatitis showed negative serologic reaction of HBV infection. The reasons were virus mutation, immune response of host, and mixed infection with other viruses.