| 羟基红花黄色素A对局灶性脑缺血后大鼠脑组织诱导型一氧化氮合酶的影响 |
| |
| 引用本文： | 盛雨辰,夏玉叶,闵旸.羟基红花黄色素A对局灶性脑缺血后大鼠脑组织诱导型一氧化氮合酶的影响[J].中国药理学通报,2006,22(9):1134-1137. |
| |
| 作者姓名： | 盛雨辰 夏玉叶 闵旸 |
| |
| 作者单位： | 上海医药工业研究院药理研究室,上海,200437 |
| |
| 摘 要： | 目的探讨羟基红花黄色素A(hydroxysaffloryellowA,HYSA)对大鼠局灶性脑缺血后脑组织中诱导型一氧化氮合酶(iNOS)的影响。方法采用大脑中动脉线栓法造成大鼠局灶性脑缺血模型,应用免疫组织化学技术检测大鼠脑组织中iNOS的表达,并观察了对大鼠行为学和脑组织梗死面积的影响。结果HYSA高、中剂量能明显抑制脑缺血后而高度表达的iNOS量,同时减轻大鼠脑梗死面积和神经功能障碍。结论HYSA能下调脑缺血所致iNOS的异常表达,这可能是其治疗脑缺血性脑血管疾病的机制之一。
|
| 关 键 词： | 羟基红花黄色素A 局灶性脑缺血 诱导型一氧化氮合酶 |
| 文章编号： | 1001-1978（2006）09-1134-04 |
| 收稿时间： | 2006-04-08 |
| 修稿时间： | 2006-06-09 |
Effects of hydroxysafflor yellow A on iNOS expression in rats of focal cerebral ischemic injury |
| |
| SHENG Yu-chen,XIA Yu-ye,MIN Yang.Effects of hydroxysafflor yellow A on iNOS expression in rats of focal cerebral ischemic injury[J].Chinese Pharmacological Bulletin,2006,22(9):1134-1137. |
| |
| Authors: | SHENG Yu-chen XIA Yu-ye MIN Yang |
| |
| Institution: | Dept of Pharmacology, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China |
| |
| Abstract: | Aim This was to study the effects of hydroxysafflor yellow A(HYSA)on iNOS expression in rats following focal cerebral ischemia. Methods Rat cerebral ischemia-reperfusion injury was induced by middle cerebral artery occlusion. The expression levels of iNOS were examined using immunohistochemical method. The neurological outcome and the cerebral infarct area were evaluated. Results The expression levels of iNOS in HYSA groups were significantly lower than those in ischemic model group. Treatment with HYSA also decreased the cerebral infarct area and the neurological deficit score. Conclusion HYSA induced down regulation of iNOS expression, which may mediate the protective effect of HYSA on cerebral ischemia. |
| |
| Keywords: | hydroxysafflor yellow A (HYSA) focal cerebral ischemia iNOS |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
