肝癌外周血微转移检测意义及其问题

目的明确外周血微转移检测在肝细胞癌（hepatocellular carcinoma，HCC）转移复发中的诊断价值。方法通过回顾文献分析HCC外周血微转移检测的方法及意义。结果HCC的外周血微转移检测目前主要有播散细胞检测与HCC特异mRNA标记检测两类，从理论上来说都被认为是早期检测转移复发的理想方法，但不同实验研究间普遍存在着相互矛盾的结论，调整改进检测手段与时间亦未能够彻底解决检测结论的冲突。结论外周血微转移检测对于深入理解HCC转移复发机理和完善临床治疗有很大意义，但理论与应用中均存在着有待改进的地方，该技术的不断完善将促进对转移复发的机理研究与检测应用。

Significance and Problems in Detection of Hepatocellular Carcinoma Micrometastasis in Peripheral Blood

Objective To determine the value of detection of micrometastasis in peripheral blood to hepatocellular carcinoma (HCC) metastasis or recurrence. Methods Reviewed the related literatures, the methods and significances of the detection of HCC micrometastasis in peripheral blood were analyzed. Results Currently, there are mainly two methods, hematogenous dissemination cell detection and HCC specific mRNA biomarker detection, for detection of HCC micrometastasis in peripheral blood. Theoretically, although they are considered as early detections of HCC metastasis or recurrence, researches still not have a abroad agreeable conclusion from different studies. After adjusting and improving the methods and detection time, different studies also have not gotten a quite consistent conclusion. Conclusion There is a great significance in detection of HCC micrometastasis in peripheral blood to understanding the mechanisms of HCC metatasis and recurrence, and also to improving the clinical therapy. Theoretically and practically, the method should be improved for facilitating the mechanism research of HCC metastasis and recurrence, and the application of detection.