性激素受体和基质金属蛋白酶在子宫内膜异位症的表达

目的检测雌、雄激素受体（ER、PR）和MMP-1在子宫内膜异位症（EMS）患者的异位内膜和在位内膜中表达,探讨三者在子宫内膜内异症发生发展中的作用。方法采用免疫组织化学PV-9000法分别检测ER、PR和MMP-1的表达。研究组：84例EMS的异位内膜和44例在位内膜;对照组：32例子宫肌瘤者正常子宫内膜。结果异位内膜组织中ER、PR的表达明显低于正常内膜组织和在位内膜组织（P〈0.01、P〈0.05）,而异位内膜组织中MMP-1的表达强度明显高于正常内膜组织（P〈0.05）;在位内膜组织ER、PR表达却明显高于正常内膜组织（P〈0.05）。结论ER、PR和MMP-1在异位内膜和EMS在位内膜中的异常表达,可能与EMS的发生发展有关。

Expression of receptor of sex hormone and matrix metalloproteinases in ectopic and eutopic endometrium of endometriosis

Objective To describe expression of sex hormone receptor(ER,PR) and MMP-1 in ectopic and eutopic endometrium of endometriosis.Methods The expression of ER,PR and MMP-1 in ectopic endometrium (84 cases) and eutopic endometrium(44 cases)in endometriosis as well as normal endome-trium(32 cases) were detected by PV-9000 of immunohistochemistry.Results The expression of ER and PR in ectopic endometrium were significantly lower than that in eutopic and normal endometrium(P<0.01,P<0.05),But the expression of MMP-1 in ectopic endometrium were higher than that in normal endometrium(P<0.05).The expression of ER and PR in eutopic endometriums were significantly higher than that in normal endometrium(P<0.05). Conclusion The abnormal expression of ER,PR and MMP-1 in ectopic and eutopic endometrium of endometriosis could be relevant to the development and progress of endometriosis.