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nm23基因在涎腺恶性肿瘤中表达的意义
引用本文:金辉喜 李金荣. nm23基因在涎腺恶性肿瘤中表达的意义[J]. 中华口腔医学杂志, 1997, 32(6): 341-343
作者姓名:金辉喜 李金荣
作者单位:湖北医科大学口腔医学院
摘    要:为了探讨nm23基因在涎腺恶性肿瘤中表达的意义,作者应用免疫组织化学方法检测了40例涎腺恶性肿瘤nm23基因表达情况,并分析了nm23基因表达变化与涎腺恶性肿瘤的临床病理及其转移的关系。结果发现,nm23低表达者其肿瘤转移率为818%,而nm23高表达者其肿瘤转移率只有34%,两者差异有高度显著性(P<0.005);nm23低表达与肿瘤大小、部位、病理类型无显著相关性(P>0.05)。结果表明nm23基因在抑制涎腺恶性肿瘤转移方面起重要作用。

关 键 词:基因  肿瘤转移  涎腺肿瘤

Significance of nm23 expression in malignant carcinoma of salivary gland
H Jin,J Li,X Chen. Significance of nm23 expression in malignant carcinoma of salivary gland[J]. Chinese journal of stomatology, 1997, 32(6): 341-343
Authors:H Jin  J Li  X Chen
Affiliation:School of Stomatology, Hubei Medical University, Wuhan 430070.
Abstract:In recent years, a tumor suppressor gene nm23 has been found to be associated with decreased tumor metastatic potential. Allelic deletion, mutation and low expression of this gene has been correlated with tumor metastatic potential in a number of tumors. We examined the expression of nm23 in 40 cases of salivary gland malignant carcinomas by immunohistochemical method. The results showed that nm23 lower expression tumors were associated with a higher rate of metastasis (81.8%) than nm23 higher expression (3.4%, P < 0.005). There is no correlation between nm23 lower expression and tumor size, location and pathologic type (P > 0.05). This result indicates that nm23 gene plays an important role in the metastasis of salivary gland malignant carcinoma.
Keywords:Genes Neoplasm metastasis Salivary gland neoplasms  
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