THE NEUROLOGICAL FEATURES OF EARLY AND 'LATENT' HUMAN IMMUNODEFICIENCY VIRUS INFECTION |
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| Authors: | B. J. BREW M. PERDICES P. DARVENIZA P. EDWARDS B. WHYTE W. J. BURKE R. GARRICK D. O'SULLIVAN R. PENNY D. A. COOPER |
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| Affiliation: | Staff Specialist, AIDS unit, St Vincent's Hospital, Sydney;Visiting Medical Officer, Department of Neurology, St Vincent's Hospital, Sydney;Neuropsychologist, NHMRC Special Unit in AIDS Epidemiology and Clinical Research, University of New South Wales;Visiting Medical Officer, Department of Neurology, St Vincent's Hospital, Sydney;Staff Specialist, Department of Neurology, St Vincent's Hospital, Sydney;Visiting Medical Officer, Department of Neurology, St Vincent's Hospital, Sydney;Staff Specialist, Bruce Hall, Dept of Gastroenterology, St Vincent's Hospital, Sydney;Director, Centre for Immunology, St Vincent's Hospital, Sydney;Medical Administrator, NHMRC Special Unit in AIDS Epidemiology and Clinical Research, University of New South Wales;Staff Specialist, Centre for Immunology, St Vincent's Hospital, Sydney, and Director, NHMRC Special Unit in AIDS Epidemiology and Clinical Research, University of New South Wales |
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| Abstract: | Neurological manifestations of unknown cause occurring in patients who become or are HIV antibody positive with presumed normal immune function have been described recently. This report adds a further six cases, all of whom had normal CD4 + cell counts either throughout the period of observation or after the episode of seroconyersion. Three had an acute presentation, two in the context of documented seroconversion consisting of one of the following: an encephalitis, an ataxia, and confusion with neuralgic amyotrophy. Three had a subacute disorder occurring at a later phase of HIV infection but before opportunistic infections or neoplasms, and marked by a static mild cognitive deficit. This report extends the range of abnormalities that may be seen at seroconversion and documents the presence of a non-progressive cognitive deficit occurring in the latent phase of HIV infection. |
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| Keywords: | HIV infection AIDS neurologic features seroconversion |
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