硝苯地平控释片3种剂量治疗稳定性心绞痛疗效比较

目的 :比较硝苯地平控释片小、中和大剂量治疗稳定性心绞痛的疗效。方法 :1 0 2例病人被随机分为 4组 ,分别接受硝苯地平控释片 30mg·d-1(n =2 7) ,60mg·d-1 (n =2 5) ,90mg·d-1 (n =2 6)和安慰剂 (n =2 4 )治疗 ,为期 6wk。结果 :经过 6wk的治疗后 ,硝苯地平控释片 3种剂量均能显著减少心绞痛发作次数及硝酸甘油消耗量 ;均能延长运动至ST压低 1mm时间和总运动时间 ;各治疗组治疗前后或与对照组比较 ,差异均有显著或非常显著意义 (P <0 .0 5或P <0 .0 1 )。临床症状总有效率分别为 81 % ,88%和 89% ;心电图总有效率分别为56 % ,60 %和 65 %。不良反应发生率 90mg组高于其余 3组。结论 :硝苯地平控释片 30 ,60和 90mg·d-1 短期治疗均能有效改善稳定性心绞痛病人的临床症状、心电图及运动能力 ,但每日剂量以低于60mg为宜

Evaluation of three doses of nifedipine controlled release tablet in treatment of stable angina pectoris

AIM: To compare the safety and efficacy of three dosages of nifedpine controlled rele ase tablet in treatment of stable angina pectoris. METHODS: One hundred and two patients with stable angina pectoris were randomly divided i nto four groups .The patients received nifedipine 30 mg·d -1 (n=27),60 mg·d -1 (n=25), 90 mg·d -1 (n=26)and placebo treatment (n =24)for 6 wk, respectively. RESULTS: All three dosages of nifedipine could reduce the attack times of angina pectoris and nitroglycerin comsumption significantly (P<0.05), prolonged the total exerc ise time and time to≥1 mm ST-segment depression, respectively (P<0.05).Th e clinical symptoms total effective rates were 83 %, 88 % and 89 %in 30, 60 and 90 mg group, respectively. The ECG total effective rates were 56 %, 60 % a nd 65 % i n 30, 60 and 90 mg group, respectively. The adverse reaction rate of the 90 mg t reatment group was higher than that of the other three groups. CONCLUSION: Nifedipine at three doses of 30,60 and 90 mg·d -1 is able to ameliorate c l inical symptoms, ischemic changes in electrocardiogram and exercise tolerance te sts. The dose should be controlled within the 60mg·d -1 .