AmpC beta-lactamases producing bacteria |
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Authors: | Okamoto R Nakano R |
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Affiliation: | Department of Microbiology, Kitasato University School of Medicine. |
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Abstract: | beta-Lactamases are the principal mechanism of bacterial resistance to beta-lactam antibiotics. In recent years, resistance due to production of beta-lactamases including extended-spectrum beta-lactamses, carbapeneases and AmpC beta-lactamses, has risen at alarming rate in clinical isolates of gram-negative bacteria. AmpC beta-lactamses are classified by whether genes locate on chromosome or plasmid. The purpose of this paper is to address the general mechanism involve in AmpC beta-lactamase production and the clinical importance of the enzymes. |
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