钙离子拮抗剂尼伐地平的波谱学解析与结构确证 |
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引用本文: | 赵兰芳,邹振兴,陈波,喻凯,李福双,谭桂山,徐康平. 钙离子拮抗剂尼伐地平的波谱学解析与结构确证[J]. 中南药学, 2014, 0(4): 333-336 |
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作者姓名: | 赵兰芳 邹振兴 陈波 喻凯 李福双 谭桂山 徐康平 |
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作者单位: | [1]中南大学药学院,长沙410013; [2]湖南方盛制药股份有限公司,长沙410205 |
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摘 要: | 目的对钙离子拮抗剂尼伐地平进行系统的波谱学解析与结构确证。方法运用热分析、圆二色谱、紫外光谱、红外光谱、核磁共振、质谱、高分辨率质谱以及X射线粉末衍射等分析手段测定样品的谱学数据,并进行系统解析与归属。结果证实尼伐地平的结构为3-甲基-5-(1-甲基乙基)-4-(RS)-2-氰基-6-甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯。结论本法测定结果准确,为尼伐地平的生产和鉴定提供较为全面的参考数据。
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关 键 词: | 钙离子拮抗剂 尼伐地平 结构分析 |
Spectral analysis and structural elucidation of calcium antagonist nilvadipine |
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Affiliation: | ZHAO Lan-fang, ZOU Zhen-xing, CHEN Bo, YU Kai, LI Fu-shuang, TAN Gui-shan, XU Kang-ping. (1. School of Pharmaceutical Sciences, Central South University, Changsha 41 O013; 2. Fangsheng Pharmaceuti- cal Co., Ltd, Changsha 410205) |
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Abstract: | Objective To determine the chemical structure of nilvadipine with systematic spectrum analysis. Methods TG-DSC, CD, UV, FT-IR, NMR, MS, HRMS, and XRD were adopted to analyze the chemical structure of Nilvadipine. Results The structure of nilvadipine was 3-methyl-5-(1-methylethyl)-4-(RS)-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3, 5-dicarboxylate. Conclusion This result is accurate and can provide a comprehensive reference for production and identification of nilvadipine. |
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Keywords: | calcium antagonist nilvadipine structure analysis |
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