Anxiolytic-like effects of group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats |
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| Authors: | Kłodzińska A Tatarczyńska E Chojnacka-Wójcik E Pilc A |
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| Affiliation: | Institute of Pharmacology, Polish Academy of Sciences, Kraków. |
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| Abstract: | We examined the anxiolytic-like activity of2-methyl-6-(phenylethynyl)-pyridine (MPEP) using the conflict drinking Vogel test in rats as a model. MPEP is a selective and brain-penetrable mGlu5 receptor antagonist, the most potent compound described so far. The results indicate that MPEP produced a dose-dependent anticonflict effect in rats. These data suggest that selective mGlu5 receptor antagonists may become a new class of anxiolytics. |
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