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Adjuvant Activity of 6-Amino-6-Deoxy-Muramyldipeptides and Their Acylamino Derivatives on the Induction of Delayed Hypersensitivity to Azobenzenearsonate-N-Acetyl-l-Tyrosine in Guinea Pigs
Authors:Ichiro Azuma   Hiroyuki Okumura   Ikuo Saiki   Yoshiro Tanio   Makoto Kiso   Akira Hasegawa     Yuichi Yamamura
Affiliation:1Institute of Immunological Science, Hokkaido University, Sapporo 060, Japan;2Department of Agricultural Chemistry, Gifu University, Kakamigahara, Gifu 504, Japan;3Osaka University, Osaka 565, Japan
Abstract:The 6-amino-6-deoxy-N-acetylmuramyldipeptides and their 6-acylamino derivatives were shown to be active as adjuvants on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-l-tyrosine in guinea pigs. However, 6-acylamino-6-deoxy-N-(acyl)muramyldipeptides were inactive as adjuvants.
Keywords:
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