Adjuvant Activity of 6-Amino-6-Deoxy-Muramyldipeptides and Their Acylamino Derivatives on the Induction of Delayed Hypersensitivity to Azobenzenearsonate-N-Acetyl-l-Tyrosine in Guinea Pigs |
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| Authors: | Ichiro Azuma Hiroyuki Okumura Ikuo Saiki Yoshiro Tanio Makoto Kiso Akira Hasegawa and Yuichi Yamamura |
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| Institution: | 1Institute of Immunological Science, Hokkaido University, Sapporo 060, Japan;2Department of Agricultural Chemistry, Gifu University, Kakamigahara, Gifu 504, Japan;3Osaka University, Osaka 565, Japan |
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| Abstract: | The 6-amino-6-deoxy-N-acetylmuramyldipeptides and their 6-acylamino derivatives were shown to be active as adjuvants on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-l-tyrosine in guinea pigs. However, 6-acylamino-6-deoxy-N-(acyl)muramyldipeptides were inactive as adjuvants. |
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