低浓度一氧化碳对大鼠谷胱甘肽过氧化物酶的影响

为探讨低浓度一氧化碳对成年及老龄大鼠谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）的影响。实验选用Ｗｉｓｔａｒ雄性健康３月龄成年及１８月龄老龄大鼠。成年鼠组暴露于自然空气、１０、２５ｍｇ／ｍ＾３ＣＯ，老龄鼠组暴露于自然空气、１０ｍｇ／ｍ＾３ＣＯ。每组均为５只。暴露方式为静式染毒，２小时／天，染毒３０天。测定全血、心组织、脑组织ＧＳＨ－Ｐｘ。结果表明，成年大鼠在２５ｍｇ／ｍ＾３ＣＯ染毒下，第３０天血液及脑组织Ｇ

Effects of Low Level Carbon Monoxide on Glutathione Peroxidase in Rats

To explore the effects of low level carbon monoxide(CO)on glutathione peroxidase (GSH P x ) in rats,the healthy 3 month old Wistar male adult rats and 18 month old Wistar male aged rats were selected as experimental animals,which were exposed to 0,10,25 mg/m 3 CO and 0,10 mg/ 3 CO respectively There were 5 rats in every group.All of the observed rats were exposed to CO statically for 30 days,2 hoursperday The activities of GSH P x in blood,heart and brain tissue of rats were determined The results showed that the activities of GSH P x in the blood and brain tissue in adult rats significantly increased at the 30th exposure day to 25 mg/m 3 CO,but those in the blood,heart and brain tissue revealed no significant variances in both of adult rats and aged rats exposed to 10 mg/m 3 CO It indicated that CO levels of 25mg/m 3 and 10 mg/m 3 for adult rats were the threshold and sub threshotd concentration respectively It was also considered that aged rats exposed to 10 mg/m 3 CO were not more sensitive than adult rats in the increase of GSH P x activities induced by CO