Association of XRCC1 gene single nucleotide polymorphisms and susceptibility to pancreatic cancer in Chinese

The human X-ray repair cross-complementing group 1 gene (XRCC1) is an important candidate gene for affecting pancreatic cancer (PC) risk. The objective of this study was to detect whether the c.1471G?>?A and c.1686C?>?G polymorphisms of XRCC1 gene influence PC risk. The association of XRCC1 genetic variants with PC risk was analyzed in 328 PC patients and 350 controls by the polymerase chain reaction-restriction fragment length polymorphism and created restriction site-polymerase chain reaction method. Our data suggested that the genotypes and alleles from these two genetic variants were statistically associated with PC risk. For c.1471G?>?A, the AA genotype was associated with the decreased risk of developing PC compared to GG wild genotype (odds ratio (OR)?=?0.43, 95 % confidence intervals (CI) 0.26–0.70, chi-squared (χ ²)?=?11.91, P?=?0.001). For c.1686C?>?G, the risk of PC was significantly lower for GG genotype in comparing to CC wild genotype (OR?=?0.48, 95 % CI 0.29–0.81, χ ²?=?7.98, P?=?0.005). The A allele of c.1471G?>?A and G allele of c.1686C?>?G genetic variants could contribute to decrease the risk of PC (for c.1471G?>?A: A vs G, OR?=?0.65, 95 % CI 0.52–0.82, χ ²?=?13.71, P??G: G vs C, OR?=?0.70, 95 % CI 0.55–0.88, χ ²?=?9.42, P?=?0.002). Our findings indicate that the c.1471G?>?A and c.1686C?>?G polymorphisms of XRCC1 gene are associated with PC risk in Chinese population.