CARMA3 is overexpressed in human glioma and promotes cell invasion through MMP9 regulation in A172 cell line |
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| Authors: | Xingjun Feng Guozhuan Miao Yipeng Han Yi Xu |
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| Affiliation: | 1. Department of Neurosurgery, General Hospital of Chinese People’s Armed Police Forces, Beijing, 100039, China
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| Abstract: | Caspase recruitment domain-containing membrane-associated guanylate kinase protein 10 or CARMA3 (CARD10) is a recently characterized oncoprotein involved in the progression of several human malignancies. The present study aims to investigate the expression pattern and biological roles of CARMA3 protein in human glioma. CARMA3 expression was analyzed in 97 glioma specimens using immunohistochemistry. We observed negative staining in normal astrocytes and positive staining of CARMA3 in 25 out of 97 (25.8 %) glioma samples. Overexpression of CARMA3 correlated with tumor grade (p?
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