Membrane stabilising properties of the selective 5-HT2 receptor agonist, (+/-)-DOI. |
| |
| Authors: | K F Martin R Kellett W R Buckett |
| |
| Affiliation: | Boots Pharmaceuticals Research Department, Nottingham, U.K. |
| |
| Abstract: | The effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a selective 5-HT2 receptor agonist, on nerve conduction in the isolated frog sciatic nerve trunk were examined. Compound action potential amplitude was concentration dependently decreased by (+/-)-DOI (EC50 = 1.2 mM), an effect that was not altered by the presence of ketanserin and with a similar potency to lignocaine. (+/-)-propranolol and disopyramide. The results indicate that (+/-)-DOI has membrane stabilising properties, in addition to its reported 5-HT2 agonist actions. |
| |
| Keywords: | |
|
|
