| 鞘内注射JNK特异性抑制剂SP600125对CCI大鼠痛行为的影响 |
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| 引用本文： | 闫哲,杨承祥,王汉兵,赵伟成,周小丽. 鞘内注射JNK特异性抑制剂SP600125对CCI大鼠痛行为的影响[J]. 国际麻醉学与复苏杂志, 2005, 30(1): 228-230,235. DOI: 10.3760/cma.j.issn.1673-4378.2009.03.010 |
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| 作者姓名： | 闫哲 杨承祥 王汉兵 赵伟成 周小丽 |
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| 作者单位： | 广东省佛山市第一人民医院麻醉科,528000;广东省佛山市第一人民医院病理科; |
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| 摘 要： | Objective To observe the effect of intrathecal administration of SP600125 on both MWT and TWL of rats after chronic constriction injury (CCI) of the sciatic nerve. Methods 40 male SD rats were randomized to deride into 5 groups (n=8). Rats in group SP5 received SP600125 5 μg after CCI; rats in group SP25 received SP600125 25 μg after CCI; rats in group SP50 received SP600125 50 μg after CCI; rats in group DMSO received 2% DMSO 10 μl after CCI; rats in group Naive received SP600125 50 μg without sciatic nerve injury. SP600125 was dissolved in 10 μl 2%DMSO solvent. On the 7th day after CCI, MWT and TWL were determined with yon Frey filaments and thermal radiation apparatus repectively after intrathecal administration of SP600125. Results Intrathecal administration certain dosage of SP600125 could attenuate the established mechanical allodynia and thermal hyperalgesia induced by CCI rather than normal rats. Conclusion Intrathecal administration certain dosage of SP600125 could attenuate the established mechanical allodynia and thermal hyperalgesia induced by CCI.
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| 关 键 词： | 鞘内注射 慢性压榨性损伤 机械痛敏 热痛敏 |
Effect of intrathecal administration of SP600125 on MWT and TWL of rats after chronic constriction injury |
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| Abstract: | |
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| Keywords: | SP600125lntrathecal administrationSP600125CCIMechanical allodyniaThermal hyperalgesia |
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