| 长效阿片拮抗剂纳曲酮抗休克作用的临床观察 |
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| 引用本文： | 呼业功,李钊,郭静萱,陈明哲,许铁,韩济生.长效阿片拮抗剂纳曲酮抗休克作用的临床观察[J].北京大学学报(医学版),1992(2). |
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| 作者姓名： | 呼业功 李钊 郭静萱 陈明哲 许铁 韩济生 |
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| 作者单位： | 北京医科大学第三医院
(呼业功，李钊，郭静萱，陈明哲)，北京医科大学生理学教研室
(许铁)，北京医科大学生理学教研室(韩济生) |
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| 摘 要： | 本文给14例收缩压在10.7 kPa(80mmHg)以下的休克患者静脉注射阿片拮抗剂纳曲酮4 mg,有 10例在注射后 5 min内,有 2例分别在 10和 20 min时收缩压上升至10.7 kPa以上。给药后2小时内血压继续续回升,但未见血压过度升高的反跳现象。共观察72小时,有11例血压和脉率均保持正常水平。结果表明:纳曲酮是一种有效的抗休克药,可促使休克患者的血压迅速而稳定地回升至正常水平。
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| 关 键 词： | 纳曲酮 休克 血压 阿片受体 |
LONG-ACTING OPIOID ANTAGONIST NALTREXONE FOR TREATMENT OF SHOCK: A CLINICAL OBSERVATION |
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| Hu Yegong,et al Beijing Medical University.LONG-ACTING OPIOID ANTAGONIST NALTREXONE FOR TREATMENT OF SHOCK: A CLINICAL OBSERVATION[J].Journal of Peking University:Health Sciences,1992(2). |
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| Authors: | Hu Yegong Beijing Medical University |
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| Abstract: | Fourteen patients diagnosed as clinical shock with systolic blood pressure (SBP) lower than 10.7kPa were given a single iv injection of naltrexone at 4 mg. Ten patients showed an increase in SBPover 10.7 kPa within 5 min, 2 showed the same effect at 10 and 20 min, respectively. The bloodpressure kept gradual increase in 2 h with no vigorous fluctuation. Eleven out of 14 patients exhibi-ted a normal blood pressure and pulse rate 72 h after the naltrexone treatment. The results indicatethat naltrexone is an effective anti-shock agent which elicites a rapid and steady recovery of theblood pressure toward normal level. |
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| Keywords: | Naltrexone Shock Blood pressure Opioid receptor |
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