Origin of malignant centrofacial granulomas: surface markers and gene rearrangement of malignant cells |
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| Authors: | J Cabane M Raphaël G Lamas Djavad Mossalayi A Dubois G Chomette P Godeau C Marty-Double J F Rossi |
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| Institution: | Department of Internal Medicine, Saint-Antoine Hospital, Paris, France. |
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| Abstract: | Malignant centrofacial granuloma (MCFG) is a clinical entity characterized by a relentless ulceration of the upper airway involving the nose, palate, and face, without any demonstrable etiology. The origin of 11 cases were analyzed with the help of cell-surface immunostaining in all and with T-cell receptor gene (TCR) rearrangement in 3. The results show that most of the cases of MCFG are in fact T-cell lymphomas with cell-surface antigens (CD2, CD7, CD3) consistent with either early or mature T lymphocytes. However, some cases exhibit B-lymphoid (CD19, CD20) or histiomonocytic (CD13, CD14) lineage-specific markers. In conclusion, despite its remarkable clinical unity, MCFG is a heterogeneous group of neoplastic diseases, most but not all of which may be classified as T-cell lymphoma. |
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