妊娠高血压综合征患者血浆内皮素、一氧化氮水平的变化

目的：探讨妊高征患者血浆内皮素、一氧化氮水平变化。方法：应用放射免疫法测定30例正常岳娠妇女及38例妊高征患者的血浆内皮素一氧化氮。结果：妊高征患者血浆内皮素水平高于正常妊娠组（P〈0．01），血浆一氧化氮水平低于正常妊娠组（P〈0．01）。妊高征患者血浆内皮素水平与平均动脉压（MAP）呈明显正相关，血浆一氧化氮水平与平均动脉压呈明显负相关。结论：血浆内皮素一氧化氮水平的变化在妊高征病理生理过程中起重要作用。

Changes of plasma endothelin and nitric oxide levels in patients with pregnancy induced hypertension

Objective:To study the changes in plasma endothelin and nitric oxide levels in patients with pregnancy induced hypertension.Methods:The plasma endothelin and nitric oxide concentrations were measured in 30 normal pregnant women and 38 women with pregnancy induced hypertension by radioimmunoassay.Results:The plasma endothelin level in the patients with pregnancy induced hypertension was increased significantly higher than that of normal pregnancy women(P<0.01).The plasma nitric oxide level in the patients with pregnaney induced hypertension was decreased significantly lower than that of normal pregnancy women(P<0.01).Significant positive correlation was found between plasma endothelin level and mean artery pressure, and significant negative correlaton was found between plasma nitric oxide level and mean artery pressure.Conclusion:The changes in plasma concentration of endothelin and nitric oxide in patients with pregnancy induced hypertension might play an important role in pathophysiology in pregnancy induced hypertension.