动脉自旋标记技术的临床应用进展

动脉自旋标记(ASL)是一种以动脉血内可自由扩散的水质子为内源性示踪剂的MR灌注成像技术,可以通过定量测量局部微血管的灌注,为疾病的临床诊断提供明确的客观依据。与传统注射对比剂的MR灌注成像方法相比,其不需注射外源性对比剂,可降低成本,并具有无创性、简单易行、可重复性等优点,因而有较强的临床应用潜力。就ASL的原理、分类、临床应用的现状和未来发展趋势予以综述。

The progress in clinical applications of arterial spin labeling technique

As a kind of MR perfusion imaging methods, arterial spin labeling (ASL) takes water in arterial blood, which is freely diffusible, as an endogenous tracer. Through quantitatively measuring local relative blood flow, ASL can provide tangible proofs for diseases diagnosis. Not like dynamic susceptibility contrast enhanced MR perfusion, it does not need exogenous contrast agent. With the advantage of noninvasiveness, simplicity, relatively lower costs and repeatability, it has strong potential in clinical application. In this review we mainly focued on the principle, categories, clinical applications, and future prospects of ASL.