| 复方丹参注射液对实验性肝损伤小鼠的保护作用 |
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| 引用本文： | 孙沛毅,张洪泉,孙云,林安平,钱涯邻. 复方丹参注射液对实验性肝损伤小鼠的保护作用[J]. 东南大学学报(医学版), 1997, 0(2) |
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| 作者姓名： | 孙沛毅 张洪泉 孙云 林安平 钱涯邻 |
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| 作者单位： | 扬州大学医学院，扬州苏北人民医院 |
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| 摘 要： | 研究复方丹参注射液对实验性肝损伤小鼠的保护作用及其机制。方法：采用急性肝损伤模型，观察小鼠血浆和肝匀浆过氧化脂质（ＬＰＯ）、血浆丙二醛（ＭＤＡ）含量及血清酶学改变。结果：复方丹参注射液防治组与对照组相比，小鼠肝损伤明显减轻，血浆和肝匀浆ＬＰＯ、ＭＤＡ含量下降，血清ＧＰＴ、ＧＯＴ降低，降低程度与用药量呈明显的量效关系。结论：复方丹参注射液对小鼠实验性肝损伤具有保护作用，其机制与抑制脂质过氧化反应有关。
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| 关 键 词： | 丹参；肝损伤；过氧化脂质；丙二醛；谷丙转氨酶；谷草转氨酶 |
Protective Effects of Compound Salvia Miltiorrhiza Bunge on Experimental Liver Injury |
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| Sun Peiyi,Zhang Hongquan,Sun Yun,Lin Anping. Protective Effects of Compound Salvia Miltiorrhiza Bunge on Experimental Liver Injury[J]. Journal of Southeast Univ: Medical Sci Ed, 1997, 0(2) |
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| Authors: | Sun Peiyi Zhang Hongquan Sun Yun Lin Anping |
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| Abstract: | Objective:To study the effect of compound injection Salvia miltiorrhiza Bunge (SMB.CO.Inj) on experimental hepatic damage of mice.Method:An acute liver injury model was used.Lipid peroxide(LPO) in plasma and liver homogenate,plasma melondialdehyde(MDA),glutamic-pyruvic transaminase(GPT) and glutamic-oxaloacetic transminase(GOT) in mice were observed and compared with those of control groups.Result:As compared with the control groups,SMB.CO.Inj. dose-dependently inhibits experimental hepatic damage and the abnormally increased of LPO in plasma and liver homogenate,as well as plasma MDA,GPT and GOT.Conclusion:SMB.CO.Inj has a protective effect on experimental hepatic damage in mice and it is related to inhibition of lipid peroxidation. |
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| Keywords: | Salvia miltiorrhiza Bunge liver injury lipid peroxides melondialdehyde glutamic-pyruvic transaminase glutamic oxaloacetic transaminase |
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