多发性硬化患者抑郁焦虑障碍与生活质量的关系

目的　探讨多发性硬化 ( multiple sclerosis,MS)患者中抑郁焦虑情感障碍发生率及抑郁焦虑与患者生活质量评定的关系。方法　采用汉密尔顿抑郁量表 ( HAMD)、汉密尔顿焦虑量表 ( HAMA)及 Spitzer生活质量指数 ( Spitzer quality of life index,QLI)量表 ,对 5 8例 MS患者及 5 0名健康人进行调查评分 ,并记录扩展的残疾状况评分 ( EDSS)和病程时间。应用多重回归统计方法对上述各项进行相关分析。结果　 MS患者抑郁情绪发生率为 48.3 % ( 2 8/5 8) ,焦虑情绪发生率为 3 2 .7% ( 1 9/5 8) ,抑郁合并焦虑发生率为 2 9.3 % ( 1 7/5 8) ,均较对照组明显升高 ( P <0 .0 1 ) ;生活质量较对照组明显减低 ( P <0 .0 1 )。抑郁焦虑情绪与生活质量有显著相关性 ,其中抑郁情绪为生活质量减低的重要预示因素。结论　MS患者中抑郁焦虑情感障碍发生率较高 ,抑郁焦虑情绪对生活质量评价有显著影响。

The Relation between Depression States and Quality of Life of Multiple Sclerosis

Objectives To investigate the incidences of depression and anxiety disorders of multiple sclerosis(MS), as well as the relation between depression states and the assessment of quality of life.Methods 58 patients with MS and 50 healthy persons were assessed by 17-item Hamilton depression rating scales (HAMD), Hamilton anxiety scale (HAMA) and Spitzer quality of life index, expanded disability status scale(EDSS) as well as the duration of illness were also recorded. A multiple factor analysis with a multiple regression analysis method was carried out on the basis of these data.Results Among them, 28 case (48.3%) were identified as depression, 19 case (32.7%) were identified as anxiety, and 17 case (29.3%) were identified as depression and anxiety. There was a highly significant correlation between depression as well as anxiety and the quality of life. Depression was the strongest predictor for reduced quality of life.Conclusions The incidences of depression and anxiety of MS is high. While depression and anxiety states have a substantial influence on the assessment of quality of life.