| 干扰素、拉米夫定抗乙肝病毒复制随访6个月-1年疗效的Meta分析 |
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| 引用本文： | 李洁,薛亚玲,黄浩正. 干扰素、拉米夫定抗乙肝病毒复制随访6个月-1年疗效的Meta分析[J]. 宁夏医学杂志, 2005, 27(11): 744-747 |
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| 作者姓名： | 李洁 薛亚玲 黄浩正 |
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| 作者单位： | <宁夏医学杂志>编辑部,宁夏,银川,750001;<宁夏医学杂志>编辑部,宁夏,银川,750001;<宁夏医学杂志>编辑部,宁夏,银川,750001 |
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| 基金项目： | 宁夏自治区医疗卫生科研计划基金项目（编号W2004034） |
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| 摘 要： | 目的 分析干扰素和拉米夫定抗乙型肝炎病毒复制的近远期效果。方法 对干扰素治疗的14项及拉米夫定治疗的5项文献研究的血清学指标。应用MeTa分析进行同质性检验和合并效应量估计。结果 干扰素和拉米夫定组血清学指标改变的同质性检验P均大于0．05，具有同质性，选用固定效应模式合并结果。ALT复常、HBeAg阴转、HBV—DNA阴转95％可信区间：干扰素组分别为1．13—2．79、0．96—1．61、1．11—1．88；拉米夫定组分别为0．84—2．56、0．62—1．84、1．01—2．98。结论 干扰素、拉米夫定治疗后随访6个月-1年结果，HBV—DNA的阴转效果均比治疗结束时有所下降。HBeAg的阴转效果无明显变化。
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| 关 键 词： | 干扰素 拉米夫定 随访 Meta分析 |
| 文章编号： | 1001-5949(2005)11-0744-04 |
| 收稿时间： | 2005-09-09 |
| 修稿时间： | 2005-09-09 |
Meta-analysis of follow-up six month and one year efficacy chronic hepatitis B with INF and LAM |
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| LI Jie,XUE Ya-ling,HUANG Hao-zheng. Meta-analysis of follow-up six month and one year efficacy chronic hepatitis B with INF and LAM[J]. Ningxia Medical Journal, 2005, 27(11): 744-747 |
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| Authors: | LI Jie XUE Ya-ling HUANG Hao-zheng |
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| Affiliation: | Editorial Board of Ningxia Medical Journal, Yinchuan 750001, China |
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| Abstract: | Objective To analyze the efficacy of interfereon(INF) and lamivudine(LAM) with chronic hepatitis B.Methods 14 articles about INF and 5 articles about LAM were taken the test for homogeneity and summary statistic.Results The fixed effect model was chose as the text for homogeneity P>0.05.ALT,HBeAg and HBV-DNA normalization 95% confidence interval(95%CI) was 1.13-2.79,0.96-1.61,1.11-1.88 respectively in group INF and 0.84-2.56,0.62-1.84,101-2.98 respectively in group LAM.Conclusion HBV-DNA normalization rate at the end of treatment is lower than that at the end of follow-up with INF and LAM.But HBeAg is no variety. |
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| Keywords: | Interfereon(INF) Lamivudine(LAM) Follow-up Meta-analysis |
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