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An appraisal of the relationship between primary hepatocellular carcinoma and hepatitis B virus |
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| Authors: | E. SUMITHRAN R. N. M. MACSWEEN |
| Affiliation: | Departments of Pathology, University of Malaya, Kuala Lumpur and University of Glasgow, Western Infirmary, Glasgow |
| Abstract: | The association between hepatitis B virus infection and primary hepatocellular carcinoma is reviewed. On the basis of serological and tissue examination there is a close link between virus infection and the tumour. While there is evidence to favour an oncogenic role for virus this is not conclusive, and other possible explanations for the relationship are discussed. |
| Keywords: | primary hepatocellular carcinoma cirrhosis hepatitis B infection hepatitis B surface antigen hepatitis B core antigen alpha-fetoprotein |