| 鼻咽癌survivin、Bcl-2及nm23-H1的表达与~(18)F-FDG PET标准化摄取值的关系 |
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| 引用本文： | 黎静,潘艳东,李志强,郭晓彤,李陆振,尹吉林,陈晓东,李向东,王卓才,陈炳旭,张伟,陈敬文.鼻咽癌survivin、Bcl-2及nm23-H1的表达与~(18)F-FDG PET标准化摄取值的关系[J].广东医学,2010,31(9). |
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| 作者姓名： | 黎静 潘艳东 李志强 郭晓彤 李陆振 尹吉林 陈晓东 李向东 王卓才 陈炳旭 张伟 陈敬文 |
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| 作者单位： | 1. 广州军区广州总医院肿瘤科,广州,510010
2. 广州军区广州总医院病理科,广州,510010 |
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| 摘 要： | 目的 探讨鼻咽癌(NPC)survivin、Bcl-2及nm23-H1的表达与18F-FDG PET标准化摄取值(SUV)的关系.方法 32例经病理组织学确诊的初治NPC患者于治疗前均行全身18F-脱氧葡萄糖PET显像,测定平均SUV值,鼻咽活检病理标本经常规石蜡切片,用免疫组织化学技术检测肿瘤组织survivin、Bcl-2及nm23-H1的表达,计算survivin、Bcl-2及nm23-H1阳性表达百分数.结果 (1)NPC中survivin阳性表达率为69%(22/32),Survivin阳性患者平均SUV值与阴性患者比较差异无统计学意义(7.68±1.64 vs 6.87±1.01, P＞0.05);(2)NPC中Bcl-2阳性表达率为72%(23/32),Bcl-2阳性患者平均SUV值与阴性患者比较差异无统计学意义(7.21±1.45 vs 7.16±2.55, P＞0.05);(3)NPC中nm23-H1阳性表达率为56%(18/32),nm23-H1阳性患者平均SUV值较阴性患者明显降低(5.90±1.06 vs 8.07±1.43),差异有统计学意义(P＜0.01).结论 NPC中存在survivin、Bcl-2、nm23-H1高表达;Survivin 、Bcl-2阳性表达与SUV值无相关性,nm23-H1阳性表达与SUV值具有相关性.
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| 关 键 词： | 正电子发射层计算机断层显像 18F-氟-脱氧葡萄糖 标准化摄取值 免疫组织化学 |
Relations between the expression of survivin,Bcl-2,nm23-H1 and the standardized uptake value (SUV) of ~(18)F-fluorodeoxyglucose in NPC |
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| LI Jing,PAN Yan-dong,LI Zhi-qiang,GUO Xiao-tong,LI Lu-zhen,YIN Ji-lin,CHEN Xiao-dong,LI Xiang-dong,WANG Zhuo-cai,CHEN Bin-xu,ZHANG Wei,CHEN Jing-wen.Relations between the expression of survivin,Bcl-2,nm23-H1 and the standardized uptake value (SUV) of ~(18)F-fluorodeoxyglucose in NPC[J].Guangdong Medical Journal,2010,31(9). |
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| Authors: | LI Jing PAN Yan-dong LI Zhi-qiang GUO Xiao-tong LI Lu-zhen YIN Ji-lin CHEN Xiao-dong LI Xiang-dong WANG Zhuo-cai CHEN Bin-xu ZHANG Wei CHEN Jing-wen |
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| Institution: | LI Jing,PAN Yan-dong,LI Zhi-qiang,GUO Xiao-tong,LI Lu-zhen,YIN Ji-lin,CHEN Xiao-dong,LI Xiang-dong,WANG Zhuo-cai,CHEN Bin-xu,ZHANG Wei,CHEN Jing-wen. Department of Oncology,Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China |
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| Abstract: | Objective To investigate the correlation between the expression of Survivin,Bcl-2,nm23-H1 and the SUV of FDG in NPC. Methods Thirty two patients with NPC comfirmed by biopsy but without previous treatment were evaluated with 18F-FDG PET/CT examination for calculation of SUV. The positive expression rates of Survivin,Bcl-2 and nm23-H1 were assessed by immunohistochemistry. Results (1) The positive expression rate of Survivin was 68.7%(22/32).There was no significant difference of SUV between Survivin positiv... |
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| Keywords: | survivin Bcl-2 nm23-H1 |
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