| 家兔抗角蛋白自身抗体独特型抗体的产生及临床意义 |
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| 引用本文： | 夏汝山,刘玉峰,李巍,李承新,万业宏,党育平. 家兔抗角蛋白自身抗体独特型抗体的产生及临床意义[J]. 细胞与分子免疫学杂志, 2001, 17(4): 371-373 |
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| 作者姓名： | 夏汝山 刘玉峰 李巍 李承新 万业宏 党育平 |
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| 作者单位： | 第四军医大学西京医院皮肤科 |
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| 基金项目： | 国家 1035课题资助，No. 96-901-01-38 |
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| 摘 要： | 目的 观察长期注射大剂量同种异体抗角蛋白自身抗体（AKautoAb)后，家兔血清中针对抗角蛋白自身抗体（AKautoAb)独特型抗体的产生，方法 肌肉注射亲和层析纯化的AKautoAb(5mg/kg)，隔日1次，连续90d，用ELISA检测血清中的抗独特型抗体，结果 注射AKautoAb的家兔产生了针对AKautoAbF(ab′）2片段的抗独特型抗体，于给药4wk血清抗体滴度达高峰，以后逐渐降低，结论 长期注射大剂量同种异体AKautoAb的家兔可产生免疫耐受性。
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| 关 键 词： | 抗角蛋白自身抗体 抗独特型抗体 免疫耐受 |
| 文章编号： | 1007-8738(2001)04-371-03 |
| 修稿时间： | 2000-09-11 |
Detection and its clinicalsignificance of anti-idiotypic antibodies directed against rabbit anti-keratin autoantibodies |
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| XIA Ru-shan,LIU Yu-feng,LI Wei,LI Cheng-xin,WAN Ye-hong,DANG Yu-ping. Detection and its clinicalsignificance of anti-idiotypic antibodies directed against rabbit anti-keratin autoantibodies[J]. Chinese journal of cellular and molecular immunology, 2001, 17(4): 371-373 |
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| Authors: | XIA Ru-shan LIU Yu-feng LI Wei LI Cheng-xin WAN Ye-hong DANG Yu-ping |
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| Affiliation: | XIA Ru-shan,LIU Yu-feng,LI Wei,LI Cheng-xin,WAN Ye-hong,DANG Yu-ping Department of Dermatology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shaanxi Province,China |
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| Abstract: | Aim To observe the production of anti-idiotypic antibodies directed against AK auto Ab in the rabbit sera after long-term, high dose allogenic AK auto Ab injection. Methods Allogenic AK auto Ab (5mg/kg)was injected intramuscularly to rabbit once every other day for 90 days. Anti-idiotypic antibodies in rabbit sera were detected by ELISA. Results Rabbits injected with AK auto Ab generated anti-idiotypic antibodies that could react to F(ab′ )2 of AK auto Ab. The titers of anti-idiotypic antibodies reached the highest levels at 4 weeks after the administration of AK auto Ab and then gradually decreased. Conclusion Rabbits could be induced to form immune tolerance when high-does allogenic AK auto Ab is administrated for long-term. |
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| Keywords: | AK auto Ab anti-idiotypic antibody immune tolerance |
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