Vitamin E and l-carnitine,separately or in combination,in the prevention of radiation-induced brain and retinal damages |
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Authors: | Orhan Sezen Mustafa Vecdi Ertekin Berna Demircan İhsan Karslıoğlu Fazlı Erdoğan İbrahim Koçer İlknur Çalık Akçahan Gepdiremen |
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Affiliation: | (1) Department of Radiation Oncology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey;(2) Department of Radiation Oncology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey;(3) Department of Biochemistry, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey;(4) Department of Radiation Oncology, 25 Aralık Goverment Hospital, 27060 Şehit Kamil, Gaziantep, Turkey;(5) Department of Pathology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey;(6) Department of Ophthalmology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey;(7) Department of Pharmacology, Faculty of Medicine, Ondokuz Mayıs University, 55050 Kurupelit, Samsun, Turkey |
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Abstract: | Our aim was to determine the effects of vitamin E and l-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 teletherapy machine. Groups 3, 4, and 5 received irradiation plus 40 kg−1 day−1 Vitamin E or 200 mg kg−1day−1 l-carnitine alone or in combination. Brain and retinal damages were histopathologically evaluated by two independent pathologists. Antioxidant enzyme levels were also measured. Radiation significantly increased brain and retinal damages. A significant increase in malondialdehyde levels as well as a decrease in superoxide dismutase and catalase enzymes in brain was found in group 2. Separate administration of Vitamin E+RT and l-carnitine+RT significantly reduced the severity of brain and retinal damages and decreased the malondialdehyde levels and increased the activity of superoxide dismutase and catalase enzymes in the brain. The findings of current study support the antioxidant and radioprotective roles of vitamin E and l-carnitine. However, the combined use of Vitamin E and l-carnitine plus irradiation interestingly did not exhibit an additive radioprotective effect. |
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Keywords: | Gamma irradiation Oxidative stress Brain Retina Vitamin E font-variant:small-caps" >l-carnitine |
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