| 2型糖尿病患者非酒精性脂肪肝与微血管病变关系的研究 |
| |
| 引用本文： | 吴景程,李晓华,彭永德,程群.2型糖尿病患者非酒精性脂肪肝与微血管病变关系的研究[J].中国实用内科杂志,2010(1). |
| |
| 作者姓名： | 吴景程 李晓华 彭永德 程群 |
| |
| 作者单位： | 上海交通大学附属第一人民医院内分泌代谢科; |
| |
| 基金项目： | 国家自然科学基金(30700381); 上海市科委引领计划项目(74119638) |
| |
| 摘 要： | 目的探讨2型糖尿病(T2DM)患者中非酒精性脂肪肝(NAFLD)与慢性肾脏疾病(CKD)及糖尿病视网膜病变(DR)的关系。方法收集2008年5月至2009年7月上海交通大学附属第一人民医院内分泌代谢科448例T2DM患者的临床资料,按是否合并NAFLD分组,比较两组间CKD和DR的发生率及其与NAFLD的联系。结果(1)448例T2DM患者中NAFLD合并率为59.4%。(2)与无NAFLD组相比,NAFLD组尿白蛋白/肌酐比值(UACR)及CKD和DR的发病率明显升高(P0.01)。(3)Logistic回归分析显示,NAFLD是T2DM患者发生CKD和DR的独立危险因素(OR=1.9,P0.05;OR=2.8,P0.01)。结论T2DM患者中NAFLD与CKD和DR密切相关,提示通过早期诊断和干预NAFLD可预防微血管并发症。
|
| 关 键 词： | 2型糖尿病 非酒精性脂肪肝病 慢性肾脏疾病 糖尿病视网膜病变 |
Non-alcoholic fatty liver disease is associated with chronic kidney disease and diabetic retinopathy in type 2 diabetic patients |
| |
| WU Jing-cheng,LI Xiao-hua,PENG Yong-de,Cheng Qun.Non-alcoholic fatty liver disease is associated with chronic kidney disease and diabetic retinopathy in type 2 diabetic patients[J].Chinese Journal of Practical Internal Medicine,2010(1). |
| |
| Authors: | WU Jing-cheng LI Xiao-hua PENG Yong-de Cheng Qun |
| |
| Institution: | WU Jing-cheng,LI Xiao-hua,PENG Yong-de,Cheng Qun.Department of Endocrinology , Metabolism,Shanghai Jiao Tong University Affiliated First People\'s Hospital,Shanghai 200080,China |
| |
| Abstract: | Objective To investigate the relationship of non-alcoholic fatty liver disease(NAFLD) with chronic kidney disease(CKD) and diabetic retinopathy(DR) in type 2 diabetic patients.Methods Prevalences of CKD and DR were assessed in 448 type 2 diabetic patients,who were divided into two groups by the presence of NAFLD.Results (1)The prevalence of NAFLD was 59.4% in type 2 diabetic patients.(2)NAFLD patients had remarkably(P<0.01)higher urinary albumin/creatinine ratio(UACR) and prevalences of CKD(30.8 vs 18.1%) a... |
| |
| Keywords: | type 2 diabetes non-alcoholic fatty liver disease chronic kidney disease diabetic retinopathy |
| 本文献已被 CNKI 等数据库收录！ |
