氟西汀治疗发作性睡病的猝倒发作

目的观察氟西汀(即百优解,fluoxetine)对发作性睡病(narcolepsy)猝倒(cataplexy)发作的治疗效果并探讨其剂量选择.方法随机选择入组之前6个月内未接受任何针对性治疗的发作性睡病患者30例.治疗开始前1周,由患者详细记录相关的临床表现和各种症状的出现频率,单独选用氟西汀20～40 mg/d,早餐后顿服.于用药的第1、2、4、6周根据患者猝倒发作次数的减少情况评价疗效.结果氟西汀对猝倒发作有良好的治疗作用,多数患者的有效治疗剂量在20～40 mg/d之间.治疗前后相比,患者的猝倒发作次数平均减少了78.83%(P ＜0.01).毒副作用少而轻且多数能在治疗过程中自行消失.结论氟西汀是治疗猝倒发作有效而安全的药物,完全可以替代三环类抗抑郁剂.

Fluoxetine in the Treatment of Cataplexy in Narcolepsy

Objective To evaluate fluoxetine and its effective dosage in the treatment of cataplexy in narcolepsy patients. Methods 30 narcolepsy subjects with cataplexy who had no direct or specific treatment since 6 months were admitted to the department for fluoxetine treatment efficacy studies. A detailed record of symptoms and frequency of cataplectic episodes each day for one week was made on each patient before starting treatment of fluoxetine 20-40 mg/d. The reduction of the numbers of cataplectic episodes per week were calculated to constitute the basis for therapeutic efficacy determinations. Results The fluoxetine is effective in the treatment of cataplexy of narcolepsy. Patients experienced a mean reduction of 78. 83% of the number of cataplectic episodes ( P < 0. 01 ). Patients reported no significant side effects with the doses used. Conclusions Fluoxetine is effective and well tolerated in the treatment of cataplexy in the narcolepsy patients.