| 吸入麻醉药对心肌收缩力的抑制作用 |
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| 引用本文： | 宋小星,彭章龙,于布为.吸入麻醉药对心肌收缩力的抑制作用[J].国际麻醉学与复苏杂志,2006,27(5):300-302. |
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| 作者姓名： | 宋小星 彭章龙 于布为 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院麻醉科,200025 |
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| 摘 要： | 常用的吸入麻醉药，如氟烷、安氟醚、异氟醚与七氟醚等，在产生全麻作用的同时，也降低了心肌的收缩力。导致这种负性肌力作用的因素有很多。近年来，对其作用机制的研究越来越深入，提出了一些新的观点，现就此予以综述。
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| 关 键 词： | 心肌收缩力 吸入麻醉药 抑制作用 负性肌力作用 全麻作用 安氟醚 七氟醚 异氟醚 |
The negative inotropic action of volatile anesthetics |
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| SONG Xiao-xing,PENG Zhang-long,YU Bu-wei.The negative inotropic action of volatile anesthetics[J].international journal of anesthesiology and resuscitation,2006,27(5):300-302. |
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| Authors: | SONG Xiao-xing PENG Zhang-long YU Bu-wei |
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| Institution: | Department of Anesthesiology, Ruijin hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China |
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| Abstract: | The negative inotropic action of volatile anesthetics has been attributed to the effect on various cellular components.For example,volatile anesthetics can not only inhibit L-type Ca~(2+) current and shorten the action potential,but also effect the Ca~(2+) sensitivity of contractile proteins.Furthermore,volatile anesthetics can decrease sarcoplasmic reticulum Ca~(2+) content,and inhibit fractional SR Ca~(2+) release,thus decrease the contractile force of cardiac muscles.And the inhibition is related to the concentration of volatile anesthetics. |
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| Keywords: | volatile anesthetics intropy |
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