冠心病患者血浆同型半胱氨酸与叶酸维生素B_(12)水平的相关性研究

目的　探讨冠心病 (CHD)患者血浆同型半胱氨酸 (Hcy)与叶酸、维生素 B1 2 浓度的变化及其相关性。方法　选择 76例经冠状动脉造影术证实为冠心病的患者 ,应用荧光偏振免疫分析法 (FPIA)测定血浆 Hcy浓度 ,离子捕获免疫分析法 (ICIA)测定血清叶酸浓度 ,非均相微粒子酶免疫分析法 (MEIA)测定血清维生素 B1 2 浓度。结果　冠心病患者血浆 Hcy浓度与正常对照组比较显著增高 (P<0 .0 0 1) ,而叶酸、维生素 B1 2 浓度则显著降低 (P<0 .0 0 1) ,以上两种变化呈负相关 (P<0 .0 0 1)。结论　高同型半胱氨酸血症是冠心病的新的独立危险因素 ,叶酸、维生素 B1 2 缺乏可能是诱发高 Hcy的重要因素。

Correlation study on plasma homocysteine and serum folic acid,vitamin B12 in coronary heart disease

Objective To explore relationship between the levels of plasma homocysteine (Hcy) and serum folic acid,vitamin B_ 12 ,and their changes in patients with coronary heart disease (CHD).Methods Plasma Hcy concentrations were measured by fluorescence polarization immunoassays (FPIA),serum folic acid and vitamin B_ 12 concentrations were measured by ion capture immunoassay (ICIA) and microparticle enzyme immunoassay (MEIA) respectively in 76 patients who were diagnosed as CHD by coronary artery arteriography.Results Plasma Hcy concentrations of patients with CHD were higher than that in normal controls (P<0 001),but serum folic acid and vitamin B_ 12 concentrations were lower than that in normal controls (P<0 001).Negative correlation was found between Hcy and folic acid,vitamin B_ 12 (P<0.001) in this study.Conclusion Hyperhomocysteinemia is an independent risk factor for CHD.Deficiency of folic acid and vitamin B_ 12 is an important factor of inducing hyperhomocysteinemia.