胃大部切除术后3年胃癌患者生活质量的EORTC QLQ-C30与QLQ-STO22联合评价

目的:采用欧洲癌症研究与治疗组织(EORTC)生活质量核心30问卷调查(QLQ-C30)和QLQ-STO22评价胃癌术后3年患者的生活质量(QOL).方法:对96名胃大部切除术后3年的胃癌患者和90名年龄和性别相匹配的门诊体检健康者进行研究.胃癌患者和健康者平均年龄分别为53.2岁±8.1岁和54.8岁±7.9岁.88.5%患者为I期胃癌术后.患者自行完成QLQ-C30量表和QLQ-STO22量表,对各评分进行统计分析.结果:胃癌患者和健康者EORTC QLQ-C30整体健康状况和QOL评分无显著差异.胃癌患者的认知功能、情绪功能和疲劳要优于对照健康者.但胃癌患者恶心和呕吐评分、经济困难、反流、进食受限和体型评分较健康者差.其他评分未见显著差异.结论:胃癌术后3年,患者的QOL整体评分基本恢复至正常水平,但在某些方面,特别是与上消化道相关的症状(如恶心呕吐、反流、进食受限等)与健康者存在差距.有必要基于这些差异采取针对性的措施进行治疗和护理.

Combined use of EORTC QLQ-C30 and QLQ-STO22 for assessment of quality of life in patients with gastric cancer after surgery for 3 years

AIM:To evaluate the quality of life(QOL) in patients with gastric cancer(GC) after surgery for 3 years with EORTC QLQ-C30 and QLQ-STO22.METHODS:Ninety-six GC patients who underwent gastrectomy 3 years ago and 90 healthy subjects were recruited into the present study.The mean age was 53.2 ± 8.1 years for GC patients and 54.8 ± 7.9 years for healthy subjects,and 88.5% of patients were diagnosed with stage I GC.There were no differences in age and gender between the two groups.QLQ-C30 and QLQ-STO22 were employed to evaluate the QOL in these subjects.RESULTS:The QLQ-C30 global QOL was comparable between GC patients and healthy subjects(60.1 ± 18.5 vs 58.3 ± 17.2,P > 0.05).The QOL with regard to cognitive functioning(71.0 ± 11.4 vs 63.6 ± 12.8),emotional functioning(79.4 ± 13.7 vs 71.2 ± 12.6) and fatigue(33.9 ± 10.6 vs 40.9 ± 11.3) of GC patients was superior to that of healthy subjects(all P < 0.05).However,the QOL with regard to nausea and vomiting(17.6 ± 10.4 vs 10.2 ± 8.7),financial difficulties(32.8 ± 14.3 vs 10.1 ± 8.6),reflux(19.4±14.3 vs 11.1± 14.7),eating restrictions(15.9 ± 14.6 vs 10.2 ± 7.8) and body image(30.8 ± 16.5 vs 15.7 ± 10.2) was inferior to those of healthy subjects.No marked differences were observed in the scores of other domains/items between the two groups.CONCLUSION:The QOL of GC patients nearly returns to normal level 3 years after surgery.The QOL related to upper gastrointestinal symptoms is significantly impaired in GC patients compared to healthy subjects.