MicroRNAs: a new therapeutic frontier for muscle wasting in chronic kidney disease |
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| Authors: | Robert H Mak Wai W Cheung |
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| Institution: | Division of Pediatric Nephrology, University of California, San Diego, Rady Children's Hospital, San Diego, California, USA. |
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| Abstract: | Multiple microRNAs (miRs) are implicated in muscle cell differentiation and muscle mass regulation. Pharmacological agents targeting miR-486 and other miRs, involved in muscle mass regulation, could potentially be developed into therapeutic agents for muscle wasting. Muscle wasting is prevalent among patients with chronic kidney disease (CKD). Xu et al. showed that miR-486 mimetic ameliorated muscle wasting in mice with CKD. miR mimetics may represent a new therapeutic frontier for muscle wasting in CKD. |
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