针刺治疗对大肠癌化疗患者胃肠道毒副反应的疗效

目的:探讨针刺治疗对大肠癌化疗患者胃肠道毒副反应的临床疗效。方法:选择大肠癌(包括结肠癌和直肠癌)患者63例,随机分为对照组31例和治疗组32例。所有患者均给予一线大肠癌化疗方案治疗,对照组患者在化疗前30 min给予盐酸托烷司琼注射液静脉滴注,治疗组患者在化疗前30 min给予盐酸托烷司琼注射液静脉滴注,同时采用针刺穴位治疗。观察周期为5 d。观察两组患者化疗后的消化道毒副反应,比较两组患者的呕吐持续天数及追加止吐药剂量。结果:化疗第1天,两组患者的呕吐、恶心程度比较,差异无统计学意义(P0.05);化疗第2天至第5天,两组患者的呕吐、恶心程度比较,差异均有统计学意义(P0.01,P0.05),治疗组患者的呕吐、恶心程度较对照组明显减轻。两组患者的呕吐持续天数及追加止吐药剂量比较,差异均有统计学意义(P0.01,P0.05),治疗组患者的呕吐持续天数及追加止吐药剂量明显少于对照组。结论:针刺联合托烷司琼治疗能有效缓解大肠癌化疗患者的胃肠道毒副反应,从而提高患者对化疗的依从性及耐受性。

Clinical Efficacy of Acupuncture on Gastrointestinal Toxic and Side Reaction in Patients with Colorectal Cancer after Chemotherapy

  Objective:To explore the clinical efficacy of acupuncture on gastrointestinal toxic and side reaction in patients with colorectal cancer after chemotherapy.   Methods: Sixty three patients with colorectal cancer including colon and rectal cancer were selected and randomly divided into the control group (31 cases) and the treatment group (32 cases). All the patients were treated with first-line chemotherapy for colorectal cancer. The patients in the control group were treated with intravenous infusion of tropisetron hydrochloride injection 30 minutes before chemotherapy and the patients in the treatment group were treated with intravenous infusion of tropisetron hydrochloride injection combined with acupuncture 30 minutes before chemotherapy. The observation period was 5 days. The gastrointestinal toxic and side reaction after chemotherapy was observed and the duration time of vomiting and the additional dose of antiemetic were compared.   Results: On the first day of chemotherapy, there were no statistical differences on the degree of nausea and vomiting between the two groups (P>0.05); from the second day to the fifth day of chemotherapy, there were statistical differences on the degree of nausea and vomiting between the two groups (P<0.01, P<0.05), and the degree of nausea and vomiting in the treatment group were significantly lighter than those in the control group. There were statistical differences on the duration time of vomiting and the additional dose of antiemetic between the two groups (P<0.01, P<0.05), and the duration time of vomiting and the additional dose of antiemetic in the treatment group were obviously less than those in the control group.   Conclusion: Acupuncture combined with tropisetron can effectively relieve the gastrointestinal toxic and side reaction in patients with colorectal cancer after chemotherapy and enhance the compliance and tolerance of chemotherapy.