Acetylator phenotyping: A comparison of the isoniazid and dapsone tests |
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| Authors: | A. Hanson A. Melander E. Wåhlin-Boll |
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| Affiliation: | (1) Department of Clinical Chemistry (Section of Toxicology) and Clinical Pharmacology, University of Lund, Sweden;(2) Department of Clinical Chemistry (Section of Toxicology) and Clinical Pharmacology, Malmö General Hospital, Sweden;(3) Department of Community Care Sciences, Dalby, Sweden |
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| Abstract: | Summary A comparison was made between the results of acetylator phenotyping by isoniazid (INH) half-life measurements based on 5 samples (0–6 h), and by determination of the ratio of monoacetylated (MAD) to unchanged dapsone (DDS) in a single sample obtained 3 h after dapsone intake. In each of 44 subjects examined, there was unequivocal agreement about classification of the subject as a rapid (INH t1/2 <2 h; MAD/DDS >0.3) or slow (INH t1/2 >2 h; MAD/DDS <0.3) acetylator. It appears that the single-sample (3 h) dapsone test is as reliable as the more laborious and time-consuming INH test for acetylator phenotyping. |
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| Keywords: | acetylator phenotyping isoniazid dapsone |
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